Celebrating the best of Cowley's heritage with classic car show
12:10pm Friday 27th July 2012 in Oxford
AUTO enthusiasts are gearing up for the highlight of the classic car calendar.
Oxfordshire?s finest Morris Minors, Minis and MGs will take over Court Place Farm in Marston for the fifth Cowley Classic Car Show on Sunday, August 12, from noon.
Most vehicles will have a connection with Cowley ? including a Morris Motors factory fire engine from the1930s.
Oxford Isis Rotary Club press officer and event co-organiser Malcolm Fearn said: ?We anticipate having some 200 vehicles, with around 150 pre-registered.
?It started off as a celebration of vehicles with a Cowley connection, Morris, Minis and MGs.
?This year we have spread our wings and said anyone who thinks their car is a classic should bring it along.?
Last year?s oldest car was made in 1907, and the oldest this time is currently a 1924 Swift.
The exhibition, organised by the rotary club, will raise funds for the Thames Valley and Chiltern Air Ambulance.
Also on display will be an Issetta bubble car, a variety of Rolls Royces and Bentleys.
There will also be Reliant Robin that three Brize Norton servicemen ? Cpl James Booth, Sgt Mark McNeil, and Snr Aircraftsman Daniel Wellstead ? aim to drive to Malta in aid of the Everyman male cancer charity.
One family will be bringing five of their seven Minis down to show off.
Tanya Field, from Headington, who met her husband Jason whilst working at what is now Mini Oxford plant, said: ?We have five between us, and our children have one each. In short, it?s because we?re insane.
?I love the Cowley show because it?s relatively small, so it?s got a real intimacy, but they have a great diversity.?
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When Mandie Miller left her job as an on-air traffic reporter in Charlotte, N.C., to have her first child, she started baking cakes for friends, just for fun. The response was so positive that in April 2009 she started a business, Got What It Cakes.
Ms. Miller put up a Web site, but about five months later her sister created a Got What It Cakes Facebook page. That's when the business started to grow. Cake orders went from two or three a weekend to six to 10; now Ms. Miller is turning away another 10 each weekend. Annual revenue at the end of her second year in business was a little more than $40,000.
Got What It Cakes is part of a new wave of online commerce: F-commerce. Social media specialists say the term was coined in 2009 to describe the growing number of businesses that sell through a Facebook page. Payvment, a start-up that provides support for Facebook shopping transactions, says it has 170,000 clients and is signing on about 1,500 stores a week, most with fewer than five employees.
(Reuters) - Chevron Corp, the second-largest U.S. oil company, reported a lower quarterly profit on Friday as oil prices weakened from a year earlier, though fatter refining margins cushioned the blow.
Second-quarter net income fell to $7.2 billion, or $3.66 per share, from $7.7 billion, or $3.85 per share, in the year-ago quarter.
The company's upstream business - oil and gas production - posted an 18 percent profit drop to $5.6 billion, while its downstream refining business saw profit jump 80 percent to $1.88 billion.
Chevron said earlier this month that industry benchmark margins on the Gulf Coast rose more than $4 per barrel to $24.89, while West Coast margins improved to $21.32 per barrel, their highest three-month average in four years.
Chevron's largest refinery is in Mississippi, with 330,000 barrels per day of capacity, while its two California plants can together refine 518,000 bpd.
Profits at larger rival Exxon Mobil Corp fell short of expectations on Thursday as oil and gas output sagged and its chemical unit faced weak margins.
Shares in Chevron rose less than 1 percent in premarket trading.
(Reporting by Matt Daily in New York and Braden Reddall in San Francisco; Editing by Gerald E. McCormick and John Wallace)
Breast cancer patients who lack RB gene respond better to neoadjuvant chemotherapyPublic release date: 26-Jul-2012 [ | E-mail | Share ]
Contact: Steve Graff stephen.graff@jefferson.edu 215-955-5291 Thomas Jefferson University
Findings initiate prospective clinical trial at the Kimmel Cancer Center at Jefferson
PHILADELPHIABreast cancer patients whose tumors lacked the retinoblastoma tumor suppressor gene (RB) had an improved pathological response to neoadjuvant chemotherapy, researchers at Thomas Jefferson University Hospital and the Kimmel Cancer Center at Jefferson report in a retrospective study published in a recent online issue of Clinical Cancer Research.
Many breast cancer patients undergo neoadjuvant therapy to reduce the size or extent of the cancer before surgical intervention. Complete response of the tumor to such treatment signifies an improved overall prognosis. Today, no marker is applied to identify tumors which will respond to such treatment, and as a result, only a subset of patients exhibit benefit from it.
"We found that loss of RB was associated with better pathological response rates in breast cancer patientsat various stages and representing multiple molecular subtypeswho were administered neoadjuvant chemotherapy," said Agnieszka Witkiewicz, M.D., Associate Professor of Pathology, Anatomy and Cell Biology at Thomas Jefferson University.
Erik Knudsen, Ph.D, Professor of Cancer Biology and the Hilary Koprowski Chair in Cancer Biology, was excited that discoveries from his life-long research on the RB-pathway were making there way into the clinic.
"This represents a potential new biomarker that could be used to tailor treatment plans for women considering neoadjuvant therapy and is a testament to the importance of cancer research," he said.
For the study, researchers, including Gordon Schwartz, M.D., Director of the Jefferson Breast Care Center and Adam Ertel, Ph.D., Bioinformatics Specialist, Department of Cancer Biology, performed a combination of gene expression profiling to identify those with RB loss and direct histological analysis in over 1,000 breast cancer patients who had undergone neoadjuvant therapy. These patients represented distinct subtypes of breast cancer and were treated with multiple different therapeutic regimens.
RB loss was associated, the team found, with an improved response to all the neoadjuvant regimens investigated in the major subtypes of breast cancer.
"Together, these data indicate that the loss of RB, which occurs relatively frequently in locally advanced disease, could be a useful tool for defining patients that experience an improved response to neoadjuvant chemotherapy," said Dr. Witkiewicz. "Based on these findings, we have initiated a prospective clinical trial at Jefferson, evaluating the association of RB and another marker, PTEN, with the response to neoadjuvant chemotherapy."
###
The clinical trial is open to patients who have a diagnosis of triple negative breast cancer and are eligible for neoadjuvant chemotherapy. (clinicaltrials.gov/ct2/show/NCT01514565).
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Breast cancer patients who lack RB gene respond better to neoadjuvant chemotherapyPublic release date: 26-Jul-2012 [ | E-mail | Share ]
Contact: Steve Graff stephen.graff@jefferson.edu 215-955-5291 Thomas Jefferson University
Findings initiate prospective clinical trial at the Kimmel Cancer Center at Jefferson
PHILADELPHIABreast cancer patients whose tumors lacked the retinoblastoma tumor suppressor gene (RB) had an improved pathological response to neoadjuvant chemotherapy, researchers at Thomas Jefferson University Hospital and the Kimmel Cancer Center at Jefferson report in a retrospective study published in a recent online issue of Clinical Cancer Research.
Many breast cancer patients undergo neoadjuvant therapy to reduce the size or extent of the cancer before surgical intervention. Complete response of the tumor to such treatment signifies an improved overall prognosis. Today, no marker is applied to identify tumors which will respond to such treatment, and as a result, only a subset of patients exhibit benefit from it.
"We found that loss of RB was associated with better pathological response rates in breast cancer patientsat various stages and representing multiple molecular subtypeswho were administered neoadjuvant chemotherapy," said Agnieszka Witkiewicz, M.D., Associate Professor of Pathology, Anatomy and Cell Biology at Thomas Jefferson University.
Erik Knudsen, Ph.D, Professor of Cancer Biology and the Hilary Koprowski Chair in Cancer Biology, was excited that discoveries from his life-long research on the RB-pathway were making there way into the clinic.
"This represents a potential new biomarker that could be used to tailor treatment plans for women considering neoadjuvant therapy and is a testament to the importance of cancer research," he said.
For the study, researchers, including Gordon Schwartz, M.D., Director of the Jefferson Breast Care Center and Adam Ertel, Ph.D., Bioinformatics Specialist, Department of Cancer Biology, performed a combination of gene expression profiling to identify those with RB loss and direct histological analysis in over 1,000 breast cancer patients who had undergone neoadjuvant therapy. These patients represented distinct subtypes of breast cancer and were treated with multiple different therapeutic regimens.
RB loss was associated, the team found, with an improved response to all the neoadjuvant regimens investigated in the major subtypes of breast cancer.
"Together, these data indicate that the loss of RB, which occurs relatively frequently in locally advanced disease, could be a useful tool for defining patients that experience an improved response to neoadjuvant chemotherapy," said Dr. Witkiewicz. "Based on these findings, we have initiated a prospective clinical trial at Jefferson, evaluating the association of RB and another marker, PTEN, with the response to neoadjuvant chemotherapy."
###
The clinical trial is open to patients who have a diagnosis of triple negative breast cancer and are eligible for neoadjuvant chemotherapy. (clinicaltrials.gov/ct2/show/NCT01514565).
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Responsible for developing and evaluating quantitative analytics / modeling. Responsible recommending lending and recovery strategy for Sterling?s consumer credit card. Makes recommendations on strategy changes as a result of multivariate analysis. Responsible for conducting statistical analyses to provide measured impacts relative to strategic initiatives. Communicates forecasted and actual results of strategy changes to key business owners to ensure consistent execution across the portfolio. Work many highly analytic solutions that require not only analytics but a business manager view. Acts as a senior level resource or resident expert on analytic / quantitative techniques.
The candidate will be a Senior Business Analyst within the Credit Risk Management team with day-to-day strategic assessment and development responsibility. He/she must have broad experience with credit exposure models and techniques for all consumer market products and have the ability to provide technical guidance to team members as well as non-technical explanations at all levels of seniority. Regular interaction with Managers and Directors in Credit Risk Management, VP?s of Credit Operations should be expected. Senior Business Analyst is an ambassador for Credit Risk Management with responsibility for local representation. Ability to make independent decisions that change policies, while being consistent with corporate strategy, while effectively escalating and sharing information with the rest of the Credit Risk Management team and Operational VP?s in Credit. A broad knowledge of financial products and markets especially consumer credit risk. Strong communication and presentation skills. Strong self-starter and motivated individual with a desire to favorably impact the business through profit maximizing opportunities. A Masters Degree in a quantitative discipline (statistics, economics, operations research or finance) or a professional certification preferred. Excellent quantitative / analytic skills. Capable of developing financial exposure models. Acute understanding of risk-return. Extremely adaptable. Highly developed skills in this role. Potential for growth to next level is evident. 3-5 years direct experience in a similar role. Experience in the development and validation of risk and financial models. Highly proficient with analytical tools, software (SAS) and data mining. Working knowledge of Adaptive Control Systems (Strategy Manager, Probe, Triad etc?)
? Strong proficiency in MSOffice.
? Knowledge of database structures and queries.
? Financial services industry experience required.
Desired Skills
? Previous experience with Monte Carlo simulation models, BASEL II exposure, model validation and development.
? Previous experience initiating and developing quantitative projects and multiple streams of complex projects.
? Previous experience managing complex reviews of systems and procedures.
? Previous experience dealing with senior level management.
? Holistic view of risk.
? Ability to balance tactical and strategic.
? Understanding of how Credit Risk Management adds value to business.
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Public release date: 26-Jul-2012
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